Endothelial Angiotensin II Generation Induced by Placenta-derived Factors From Preeclampsia
نویسندگان
چکیده
منابع مشابه
Redefining preeclampsia using placenta-derived biomarkers.
1 Acute maternal complications include eclampsia, stroke, placen-tal abruption, disseminated intravascular coagulation, HELLP (hemolysis, elevated liver enzymes, low platelets), liver hemorrhage or rupture, pulmonary edema, adult respiratory distress syndrome, acute renal failure, and death. 2 Preeclampsia complications account for more than 50 000 maternal deaths annually. 2,3 In developing co...
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Preeclampsia remains a leading cause of maternal and fetal mortality, due to ineffective treatment and diagnostic strategies, compounded by the lack of clarity on the etiology of the disorder. Although several clinical and biological markers of preeclampsia have been evaluated, they have proven to be ineffective in providing a definitive diagnosis during the various stages of the disorder. Exos...
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CONTEXT Placenta-derived circulating factors contribute to the maternal endothelial dysfunction underlying preeclampsia. Endothelial colony forming cells (ECFC), a sub-population of endothelial progenitor cells (EPCs), are thought to be involved in vasculogenesis and endothelial repair. Low vitamin D concentrations are associated with an increased risk for preeclampsia. OBJECTIVE We hypothesi...
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Preeclampsia (PE) is a life-threatening complication of pregnancy. The precise origin of PE remains obscure. Placenta has been considered to play a central role in its pathology. Here we present a brief overlook of placenta related pathogenic factors that might be involved in the pathology changes of PE. A series of factors that correlated with placenta pathology have been regarded attributed t...
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α -Asarone is the major therapeutical constituent of Acorus tatarinowii Schott. In this study, the potential protective effects of α -asarone against endothelial cell injury induced by angiotensin II were investigated in vitro. The EA.hy926 cell line derived from human umbilical vein endothelial cells was pretreated with α -asarone (10, 50, 100 µmol/L) for 1 h, followed by coincubation with Ang...
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ژورنال
عنوان ژورنال: Reproductive Sciences
سال: 2008
ISSN: 1933-7191,1933-7205
DOI: 10.1177/1933719108322432